Introduction: Increased human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) cases in Indonesia create a new social problem, which must be followed up immediately. In this study, we created a modified alarm medicine box that can help HIV patients undergoing antiretroviral therapy (ART). We hope this tool will assist HIV patients in remembering to take their antiretroviral drugs. Aim of the study was to know the effect of a modified alarm medicine box, as a tool to assist HIV patients undergoing ART.