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General Remarks1 H NMR spectra were recorded at 300 or 400 MHz with CDCl3 as solvent. 13 C-NMR spectra were obtained at 75.4 or 100.59 MHz in CDCl 3 . Chemical shifts were determined relative to the residual solvent peaks (CHCl3, δ = 7.26 ppm for hydrogen atoms, δ = 77.0 for carbon atoms).

An efficient user-friendly method of acylation of Grignard reagents to selectively synthesize ketones is presented, which is assisted by simple amides such as NMP, or DMF. The present chemoselective method tolerates a variety of functional groups such as ketone, ester, nitrile and other functional groups.

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