The novel coronavirus disease (COVID-19) or also known as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been recognized as the cause of respiratory infection in Wuhan, Hubei Province, China, in late December 2019. As of April 5, 2020, this epidemic had spread to worldwide with 12,03,485 confirmed cases, including 62,000 deaths. The World Health Organization has declared it a Global Public Health Crisis. Coronavirus causes respiratory illness coughing, sneezing, breathlessness, and fever including pneumonia. The disease is transmitted person to person through infected droplets. At present, the research on novel coronavirus is still in the primary stage. Based on the published study, we thoroughly summarize the history and origin, microbiology and taxonomy, mode of transmissions, target receptor, clinical features, diagnosis, prevention, and treatment about COVID-19. This short report writes in hope for providing platform to community and researcher dealings against with the novel coronavirus and providing a reference for further studies.

: Currently, mankind is fighting against an invisible enemy. The novel Corona virus disease (COVID-19) has been spreading at a rapid rate across the world, which made World health Organization (WHO) to declare it as a pandemic disease. COVID-19 is acute respiratory tract infection that was first reported in December 2019, initially presented as pneumonia of unknown etiology in a group of patients in Wuhan, a city in the Hubei Province of China. Sometimes corona virus from animals infect human and spread further via human to human transmission similar with the case of Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome related coronavirus (SARS-CoV), and yet again with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), previously referred to as 2019-nCoV (COVID-19). SARS-CoV-2 is an extremely pathogenic virus and is crushing the health systems of well-equipped developed countries. According to WHO situation report updated on October 25, 2020 over 42 million cases and 1.1 million deaths have been reported globally. Since the figure of cases continues to increase, these viruses create a threat to global public health. This review summarizes an overview on the study of novel coronavirus including origin, epidemiology, etiology, targets for viral entry and describes the clinical manifestation, diagnosis, and therapeutics used in clinical settings. Furthermore, our review focuses on the most up-to-date clinical information for the effective management, prevention, and counseling provided to control COVID-19 worldwide.