Objective?Report a modification of the ?rescue flap? technique using a direct endonasal approach with a partial superior septectomy for approaching pituitary tumors developed in our institution. Design?Prospective study. Setting?Hospital Universitario ?Dr. Jos? Eleuterio Gonz?lez,? Universidad Aut?noma de Nuevo Le?n. Main Outcome Measures?Since April 2015, we have performed 19 cases employing a direct endonasal approach with partial superior septectomy. Results and a technical note are described below. Results?Nineteen patients were included in this report. Six patients presented transoperatory cerebrospinal fluid (CSF) leak, so a nasoseptal rescue flap was harvested. No patients developed postoperative CSF leak in this group. Two patients were submitted to a second surgical procedure. Nasoseptal flap was harvested without complications. In both patients, the size of the flap was enough to cover the dural defect and avoid CSF leak. Conclusion?Direct endonasal approach with a partial posterior septectomy allows enough exposition of the sphenoidal sinus while preserving the nasoseptal septum with the possibility of a successful rescue flap when needed.