A B S T R A C T The concentration of kynurenine has been measured in the serum of patients with rheumatoid arthritis and in a control group. The mean serum concentration was 2.27 ± 0.688 ug/ml for patients with rheumatoid arthritis and 2.95 + 0.825 ,ug/ml for the control group.Kynurenine: creatinine clearance ratios were higher in the rheumatoid arthritis than in the control group. These data suggest that the increased urinary excretion of kynurenine by patients with rheumatoid arthritis is due at least in part to renal factors.

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