Aims and objectivesTo describe the importance of, and methods for, successfully conducting and translating research into clinical practice.BackgroundThere is universal acknowledgement that the clinical care provided to individuals should be informed on the best available evidence. Knowledge and evidence derived from robust scholarly methods should drive our clinical practice, decisions and change to improve the way we deliver care. Translating research evidence to clinical practice is essential to safe, transparent, effective and efficient healthcare provision and meeting the expectations of patients, families and society. Despite its importance, translating research into clinical practice is challenging. There are more nurses in the frontline of health care than any other healthcare profession. As such, nurse‐led research is increasingly recognised as a critical pathway to practical and effective ways of improving patient outcomes. However, there are well‐established barriers to the conduct and translation of research evidence into practice.DesignThis clinical practice discussion paper interprets the knowledge translation literature for clinicians interested in translating research into practice.MethodsThis paper is informed by the scientific literature around knowledge translation, implementation science and clinician behaviour change, and presented from the nurse clinician perspective. We provide practical, evidence‐informed suggestions to overcome the barriers and facilitate enablers of knowledge translation. Examples of nurse‐led research incorporating the principles of knowledge translation in their study design that have resulted in improvements in patient outcomes are presented in conjunction with supporting evidence.ConclusionsTranslation should be considered in research design, including the end users and an evaluation of the research implementation. The success of research implementation in health care is dependent on clinician/consumer behaviour change and it is critical that implementation strategy includes this.Relevance to practiceTranslating best research evidence can make for a more transparent and sustainable healthcare service, to which nurses are central.

Highlights Source isolation and quarantine for infectious diseases is associated with a range of intended and unintended consequences. Patients in isolation quarantine with SARS-CoV-2 and COVID-19 report a range of positive and negative intended and unintended consequences. Personal planning, access to information, social and family resources, communication and the physical environment are significant mediators of the patient experience of isolation and quarantine.