What Is Known about This Topic? • Both Graves' disease and autoimmune hypothyroidism were described in patients with resistance to thyroid hormone beta (RTHβ). • Undiagnosed RTHβ can lead to misdiagnosis of Graves' disease. The coexistence of these two diseases presents a diagnostic challenge. What Does This Case Report Add? • Autoimmune hypo-and hyperthyroidism may coexist in kindred with RTHβ. • A rapid increase of suppressed thyroid-stimulating hormone contrasting with persistently elevated thyroid hormones during medical treatment of Graves' disease may indicate RTHβ.
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