Background : Leptospirosis is an acute anthropo-zoonotic infection with multiple system involvement, caused by pathogenic strains of Leptospira interrogans . It can be associated with fatal consequences and has been a underreported disease in India. This study is aimed at determining the frequency of leptospirosis among Objective: patients of all age groups. Retrospective data of IgM ELISA for leptospirosis was retrieved for analysis. Se Methods: rum samples were collected and processed for IgM ELISA. A total of 1087 serum samples were received over a period of one year from April 2022 to March 2023 for IgM ELISA for leptospirosis. Leptospirosis was diagnosed in 159 ( Results: 14.63%) patients and majority of them were observed between July to September with slight female predominance, male to female ratio of 1:1.1.

Background and Objective: Scrub typhus is an endemic zoonotic infectious disease caused by the rickettsial bacteria Orientia tsutsugamushi, an obligate intracellular microbe. It is a serious public health problem in the Asia-Pacic region. The aim of this study was to identify the prevalence of scrub typhus in DRPGMC, a tertiary care hospital in Northern India. Methodolgy: A total of 2187 serum samples of 1022 males (46.73%) and 1165 females (53.27%) with suspected scrub typhus were received in the Department of Microbiology, DRPGMC over a period of 2 years from November 2019 to October 2021. Scrub typhus was tested by IgM ELISA (Inbios International, USA). Scrub typhus was diagnosed in 322 (14.72%) patients and the majority of them Results: were observed from August to November. Serum reactive test in females (61.80%) were in predominance as compared to serum reactive test in males (38.20%) with a ratio of 1.6:1. Majority of the samples (71.05%) were from age group 19 years to 60 years and least (4.12%) from age group 13 years to 18 years. Conclusion: The number of cases of Scrub typhus disease is increasing in North India and it is a matter of great concern. Health education campaigns focusing on the awareness of disease, quick diagnosis and prompt management is required to minimize morbidity and mortality from the disease.

We report a rare case of Rhino-orbital cerebral mucormycosis ( invasive mucormycosis) caused by Rhizopus homothallicus in patient of uncontrolled diabetes mellitus. The organism was isolated from nasal scrapping and tissue obtained after surgery and was identied after fungal culture.