Rheumatoid arthritis is a chronic systemic inflammatory disease whichinvolve multiple joints  of the body.The clinical symptoms of the Rheumatoid Arthritisresemble with Amavata described in Ayurvedic literature. In thisdisease, the vitiated Vatadosha and Ama spread all along the body and  localisein kaphasthana likejoints and producing symptoms like pain, stiffness, swelling, tendernessetc.Treatment principle recommended are to correct the status of the digestive fireof the bodyand balance of Vata in the body. In this case, a male patient of 28 years old presented with the symptoms of inabilityto walk and stand without support associated with pain, swelling and  stiffnessover multiple jointsalong with deformity of hands. Pain was assessed by Visual analogue score(VAS).The patient was admitted in IPD of the hospital andtreatedwith Ayurvedic  medicines and Panchakarma therapy for 28 days. Remarkable improvement was seen in pain, swelling and stiffness after the treatment.