No abstract

Multitarget-directed medicines (hybrid drugs) are an effective therapeutic option for multifactorial illnesses. In this study, novel 2-phenoxy-N-phenylacetamide hybrids with various heterocyclic scaffolds such as 2-amino-3cyano-4H-chromene, 2-amino-3-cyanopyrano[3,2-c]chromene, and 6-amino-5-cyano-1,4-dihydropyrano[2,3c]pyrazole were efficiently synthesized. A three-component reaction of the relevant 2-(4-formylphenoxy)-N-(aryl)acetamide with one equivalent of malononitrile and the appropriate active methylene reagent, such as dimedone, 4-hydroxycoumarine or 3H-pyrazol-3-one, is used as the synthesis approach. The structures of the novel compounds were confirmed using a variety of spectra.