Leiomyoma arising from adrenals are extremely rare with less than 20 cases reported in medical literature. Leiomyomas, though benign lesions, may frequently be confused with a malignancy, both clinically and on imaging studies, especially when they occur at atypical sites like the adrenals. We present a 42-year-old lady with cachetic symptoms, abdominal swelling and dragging sensation for 6 months, having a 10 cm diameter non-tender firm palpable abdominal mass, which on computed tomography was diagnosed to be a 12.2 × 10.3 × 8.0 cm heterogeneously enhancing adrenal mass having absolute and relative contrast washout values suggestive of malignancy. The tumor was hormonally inactive. Left adrenalectomy was done. Resected specimen weighed 91 g measuring 12 × 10 × 8.0 cm. Histopathology revealed a well-circumscribed and encapsulated benign spindle cell arranged in fascicles and whorls confirming leiomyoma. In the last evaluation 6 months after surgery, there was no evidence of tumor recurrence. This is the largest adrenal leiomyoma ever reported. Leiomyomas have a varied age of presentation (2 -72 years, median: 38) with female preponderance. They are usually unilateral and hormonally inactive. Human immunodeficiency virus and Epstein-Barr virus infections have been observed in 44.44% and 16.67% of cases respectively. However, direct link between immunodeficiency and adrenal leiomyoma has not been established. Adrenal leiomyoma can present as huge abdominal masses clinically mimicking malignancy, and radiologic investigations can also be misleading. Adrenal leiomyoma should always be considered in the differential diagnosis of huge unilateral non-functional incidentally detected adrenal lesions.

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05).Plasma vit-c level of other GI malignancies and non GI malignancies are also less than healthy volunteers.Equal level of Vit C both in cancer stomach and APD patients which is lower than that of control group.Consumption of vitamin C rich food is protective against cancer stomach by its anticarcinogenic properties.The difference between vit-c rich food consumption between cancer stomach patient and healthy volunteers is statistically significant(p value<0.05). Conclusion:-Plasma level of vit-c is significantly lower in cancer stomach

Severe megaloblastic anemia presenting with hemolytic anemia, thrombocytopenia and schistocytosis resemble microangiopathic hemolytic anemia. Presence of scistocytes falsely decreases the Mean corpuscular volume. Toestimate the degree of schistocytosis in megaloblastic anemia with hemolytic blood picture and its correlation with the lowering of MCV. 60 cases of megaloblastic anemia.30 patients of megaloblastic anemia with hemolysis(cases) and 30 patients without hemolysis(clinical control)were taken. Complete blood count, Peripheral smear examination, schistocyte count, serum bilirubin, LDH, Homocystine was done. Mean age of clinical control group was 22 where as that of cases was 14.1 years. Mean serum homocysteine level was increased in both clinical control group and cases. In our study of 30 megaloblastic anemia patients with hemolysis (case), 29 had &#62;1% of schistocytes in their peripheral blood picture. There is a positive correlation between percentage of schistocytes and homocysteine and a negative correlation between MCV and homocysteine. There is a statistically significant negative correlation existing between percentage of schistocytes and MCV.Presence of scistocytes in peripheral blood should not be always considered as MAHA, and lowering of MCV should not be confused as microcytic hypochromic anemia. Presence of macroovalocytes and hypersegmented neutrophils can be a clue for diagnosis of megaloblastic anemia with hemolysis in such type of cases.