MRI utilizing the hepatobiliary agent gadoxetate has the highest overall sensitivity and PPV, and may be the single optimal method for diagnosis of HCC. Non-contrast-enhanced US has the lowest sensitivity and PPV. More rigorous reference standards are needed to compare the performance of contrast-enhanced US with CT and MRI. Differences in sensitivity and PPV between CT and conventional gadolinium-enhanced MRI are not statistically significant overall.

This study has the longest follow up reported so far and demonstrating that subthreshold micropulse diode laser photocoagulation has a beneficial long-term effect on visual acuity and resolution of CSME with minimal chorio-retinal damage.