Abstract-Ethanol extract from the leaves of Platycladus orientaliswere investigated for their anthelmintic activity against Pheretima posthuma. Three concentrations (1%, 2.5% and 5%) of extract were studied in activity, which involved the determination of time of paralysis and death of the worm. The extract exhibited significant dose dependent anthelmintic activity. Piperazine citrate in same concentration as that of extract was included as standard reference and distilled water as control. The anthelmintic activity of ethanol extract of Platycladus orientalishas therefore been demonstrated for the first time.