Resolution of the racemic amino alcohol derivatives 1-6 is readily achieved to obtain enantiomerically enriched compounds using chiral 1,1'-bi-2-naphthol and boric acid in solvents such as CH(3)CN, THF, and MeOH. Purification of the diastereomeric mixture 7 has also been carried out following this method. The corresponding intermediate ammonium borate complexes were also characterized by X-ray diffraction methods.

Airway Hyperresponsiveness (AHR) is one of the key features of asthma and chronic obstructive pulmonary disease (COPD), where the airway sensitivity is increased. The research suggested that there is a relation between inflammatory state and severity of hyperresponsiveness of the airway, though the causative agents and consequences are different in asthma and COPD. However, before estimating hyperresponsiveness, there is a need to understand the consequences of airway inflammation, which are different in asthma and COPD. Over the past decades, there was an increased interest in unfold the multidimensional link between airway inflammation and hyperresponsiveness. This raises the hope for the future in development of diagnosis and treatment options for AHR. This short note intends to summarize the clinical correlation between airway inflammation and hyperresponsiveness and the significance of measurement of hyperresponsiveness.

Understanding the molecular basis of life is at the center today, however, advances in the field of Molecular Biology and genomics improved the compassionate of the genetic basis of diseases in human. There is an increased interest in the function of non-coding RNA transcripts in early diagnosis and treatment to various diseases. MicroRNAs are classes of small non-coding RNAs that consist of 22-25 nucleotides, which are one of the most current forms of molecular characterization of tumours. The target MicroRNA regulates the mRNA translation that causes the subsequent decrease in the protein expression. This paper aims to review some of the accumulated literature that has proven that miRNAs are strong biomarkers in diagnosis and treatment of life threatening diseases such as cancer.