Older adults of Mexican origin are often underserved, especially those residing in nursing homes. The purpose of this study was to examine if there was a relationship among risk factors associated with depression and anxiety in older adults of Mexican origin. Using a quantitative correlational design, the relationships were assessed with a demographic questionnaire, the Geriatric Depression Scale (GDS), and the Beck Anxiety Inventory (BAI). A sample of 150 elders of Mexican origin residing in nursing homes in a Texas-Mexico border city were examined using two multiple regression analyses. Data analysis indicated that there was a relationship between risk factors associated with depression and anxiety. Data from this study confirmed that a high score on ADLs predicted greater depression and anxiety while female gender predicted higher anxiety and frequent family support predicted low anxiety.