The present report is concerned with the synthesis novel Schiff base ligand by condense 6-Amino Penicillinic acid with Salicyldehyde. The ligand was characterized by 1 H-NMR, 13 C-NMR, mass spectrometry, UV-Vis and FT-IR studies. The ligand have got more than one moiety which are capable of chelation, therefore complexes of Co(II), Ni(II), Cu(II), and Zn(II) were prepared. These complexes were characterized by UV-Vis, FT-IR, magnetic susceptibility and Molar conductivity studies. All these techniques indicate 1:2 stoichiometry of synthesized complexes. In all the complexes, Schiff base ligand acts as a tridentate ligand. Finally, the ligand and complexes have been screened for their antibacterial activity against four types of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus facials and Proteus mirabilis) then it isolated from different classes of ulcerative infections while L showed to be tridentate ligand with single negative charge through three active groups, L has been associated with metal ions to form the claw complexes to get octahedral shape. The prepared ligand and its complexes illustrated a good inhibitory ability towards the three varieties bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Proteus mirabilis), while the four complexes failed to be suggested in treatment of ulcers that caused by Streptococcus facials. So, the prepared compounds could be good alternatives to the common drugs which are used in treatment of ulcers.

Serotonin is synthesized by conversion L-tryptophan into 5-hydroxytryptamine in the body by using two catalyze factors are tryptophan hydroxylase and 5-hydroxytryptophan decarboxylase, it exhibits a growth stimulatory effect on several types of carcinoma, carcinoid and other tumor cells. In contrast, few data are available on serotonin involvement in cancer cell migration and metastatic processes. Serum serotonin level was found to be suitable for prognosis evaluation of urothelial carcinoma in the urinary bladder, adenocarcinoma of the prostate and renal cell carcinoma. Subjects: 201 patients with malignant tumors, 74 patients with different benign tumors and 83 healthy individuals were enrolled in the present study. Results: Outresults show a significant increase (p=0.011 and 0.043) of serum serotonin levels in malignant tumors group when compared with those of benign tumors (as a pathological controls) group, and healthy individuals groups; respectively. No such results were shown when the two control (benign tumors and healthy individuals) groups were compared together. Conclusion: Increase of serotonin could be related to activation of the serotonergic receptors sensitivity.

This study was designed to evaluate the effect of the oxidative stress in sera of young patients without a family history of hypertension, then find the relation of it to lipid profile. The study involved 56 young healthy (30.5 ± 4.7 years) and 23 healthy elderly volunteers (66.3 ± 3.5 years), these individuals were compared with 67 patients (28.6 ± 5.0 years), attending the Gastro Intestinal and Liver Centre at Al Sader Medical City and several specialized clinics in Najaf government. Malondialdehyde level was measured by TBARS assay as reflection to the oxidative stress effect. Using standard enzymatic assays, TG, TC, HDL-C, VLDL--C, and LDL-C values were measured for patients and controls on the same day of sample obtainment. Levels of serum MDA, TG, VLDL-C, and LDL-C were significantly raised (p<0.005) in hypertensive patients group when compared with young and elderly controls, while non significant variations were obtained when the control groups were compared together. Daytime SBP and DBP were both strong positive correlated (r=0.82, p<0.005 for SBP, and r=0.95, p<0.005 for DBP) with the MDA in hypertensive patients, but in elderly controls only the correlation between SBP and MDA levels was statistically significant (r=0.61, p<0.005). Sera TG, VLDL-C, and LDL-C levels showed the same of MDA results when they were correlated to SBP and DBP, while correlations between blood pressure with sera TC were moderate positively in the study groups. In spite of; HDL-C levels in hypertensive patients were within the levels of those of two control groups, HDL-C levels showed negatively correlation with both SBP and DBP. Notably, there was a positive correlation (r=0.60, p<0.005) between serum LDL-C levels and SBP of elderly controls, no such correlations were observed when the relation was between Daytime SBP and DBP and VLDL-C or LDL-C of young controls the highly significant positive correlation (r = 0.94 at p<0.005) of MDA and TG of the hypertensive patients. Significant positive correlations were also observed for MDA with VLDL-C (r = 0.74 at p<0.005), and with LDL-C (r = 0.71 at p<0.005). It is well known that the endogenous female sex hormones have significant effect on lipid levels, according to that, testing the gender effect was occurred. MDA level in the study subgroups revealed a significant increase (p<0.005) in male patients when compared to females, while, student's t-test failed to exhibit significant changes among male and female subgroups in the control groups. Except for the significantly variation (p<0.005) of TG in the patient subgroups, all the other lipid profile parameters showed no significant differences between male and female subgroups. Concerning the controls' subgroups, TG, TC, HDL-C, VLDL-C, and LDL-C were comparabltween male and female subgroups. Finally, treatment for hypertension is similar for all demographic groups, but socioeconomic factors and lifestyle may be barriers to BP control in some patients, therefore; dealing with transitory hardships and arrangement of food style may be ...

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The present study was designed to investigate the presence of mannose binding lectin (ManBL) in the sera and tissue samples of patients with tumoral (benign & malignant) kidney in addition to patients with non tumoral kidney affection, in order to establish the possibility of using serum and tissue ManBL test for diagnosis and epidemiological testing of kidney cancers. Participants of the present study were 96 patients at the age range 12-80 years; they were attending by different hospitals in Najaf (basically) and Karbala, and 46 healthy individuals within the same age range of the studying patients groups. Specific hemagglutination activity levels were revealed a significant increased (p < 0.001) in the sera and tissues of the patients with the malignant tumors specimens in comparison to that of pathological controls and healthy individuals. Serum and tissue hemagglutination activity levels were significantly higher (p < 0.001) in patients with metastatic disease compared with patients with localized tumors. While, the levels of the hemagglutination activity were approximate at patients with the end malignant kidney tumors stages. Upon electrophoresis of the study samples, the results reflected presence of changes in some proteins and glycoproteins bands presents in these samples. Using hydrophobic affinity chromatography, ManBLs were purified from sera of malignant, benign kidney tumors and non tumoral kidney diseases in addition to healthy individuals groups. The purified lectins were found to be glycoprotein with 77.45 KD as an approximate molecular weight and its sugar content was equal to13.5%. The maximum concentration of purified ManBL was found at patients with malignant kidney tumors.The results revealed that the highest hemagglutination activity of purified ManBL occurred with O + RBCs, at pH 7.4, and 37˚C. ManBL (regardless of its origin) lost the hemagglutination activity, completely, in the presence of EDTA. A result that indicates that the present purified the human ManBLs is a calcium dependent type. EXPERIMENTAL Patient and Control IndividualsThe present study involved 96 patients (55 cases with malignant kidney tumors, 23 cases with benign kidney tumors, and 18 cases with non tumoral kidney diseases) with the age range 10-80 years, in addition to 46 healthy individuals, at the same age range.