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The 5-endo-trig-type cyclization has been performed using a Pd-bis(isoxazoline) catalyst. The present cyclization of β,γ-unsaturated carbonyl compounds gave γ-butenolides and 3-pyrrolin-2-ones in good to excellent yields.

Fused pyrimidine derivatives R 0515 A Novel One-Pot Synthesis of 2-Aryl-4(3H)-quinazolinones Using Room Temperature Ionic Liquid as Reaction Medium as well as Promoter. -(POTEWAR, T. M.; NADAF, R. N.; DANIEL, T.; LAHOTI, R. J.; SRINIVASAN*, K. V.; Synth. Commun. 35 (2005) 2, 231-241; Div. Org. Chem., Natl. Chem. Lab., Pune 411 008, India; Eng.) -R. Staver 29-166

Potassium N-methyltrifluoroborate isoindolin-1-one was synthesized and used in Suzuki-Miyaura palladium-catalyzed cross-coupling reactions with aryl and heteroaryl chlorides to prepare 29 examples of substituted N-benzyl isoindolin-1-ones. The new approach benefits from mild reaction conditions that tolerate a variety of functional groups. In addition, because of the large number of commercially available aryl and heteroaryl chlorides that can serve as coupling partners, the approach readily provides access to libraries of substituted N-benzyl isoindolin-1-ones.