Pottali Kalpana is a consolidated form of mercurial preparation which incorporates the Pota Bandha of Parada. Pottali is a type of preparation which is emerged as a result of Parada Murchana. Murchana is a procedure in which mercury is ground thoroughly with other herbo-mineral drugs to make it therapeutically efficient. Pottali is a highly potent, concise form of medicament which depicts maximum potency in low dosage form. The peculiarity of Pottali lies in its typical shape, form and preparatory methods. The present article gives a review on different preparatory procedures, types mentioned in various classical text books, dosage, mode of administration and significance of Pottali Kalpana.