To assess the surgical outcome of supine percutaneous nephrolithotomy (PCNL) in patients with comorbidities. Materials and methodsWe retrospectively reviewed the data of 15 patients who underwent supine PCNL at our centre from September 2019 to May 2021. Preoperatively, a complete examination of the patients, along with biochemical and radiological investigations, was done. The data, which included patient demographics, comorbidities, complexity of renal calculi, complications, and stone clearance rate, were collected from the patients' medical records. ResultsPatients aged between 31 and 70 years were included in the study. The mean (SD) BMI was 26.01 (2.31).Twelve patients (80%) were overweight with a BMI of 25.3 to 29.3 kg/m 2 . The most common comorbidities were diabetes (33.3%) and hypertension (26.7%). In our study, six patients were American Society of Anesthesiologists (ASA) grade 3 (40%), followed by grade 2 in five patients (33.3%), grade 4, and grade 1 in two patients (13.3%) each. The Guy's Stone score was one in nine patients (60%) and two in six patients (40%). Complete clearance was achieved in 13 (86.7%) patients. Two patients (13.3%) had a stone clearance of more than 80%. Data analysis showed that 14 patients (93.3%) had no perioperative complications. Postoperative abdominal distension was noted in one patient (6.7%), which was managed conservatively (Clavien-Dindo grade 1). We did not encounter any cases of organ injury following supine PCNL. Postoperatively, none of our patients received blood transfusions. ConclusionOur study shows that supine PCNL is a good surgical option, especially for high-risk patients with good stone clearance and low complication rates.