Abstract:The study was undertaken to compare lowering of blood pressure in pregnant women with hypertensive emergency by IV Labetalol and IV Hydralazine and to find out which drug produces better effect. This prospective type of interventional study was conducted in SMS Medical College, Jaipur among 226 women admitted with SBP ≥ 160 or DBP ≥ 110 mmHg or both. Women divided in 2 groups (113 each) devided randomly: Labetalol (Group-A), Hydralazine (Group-B).We measured the difference between pretreatment and after treatment mean arterial blood pressure. Pretreatment mean arterial blood pressure was 127.40±40 and 126.61±6.475 mmHg in labetalol and Hydralazine group respectively. After treatment mean arterial blood pressure was 112.25±5.821 and 109.27±14.30 mmHg in labetalol and Hydralazine group respectively. Mean arterial blood pressure change was 15.14 ± 8.02 mmHg in labetalol group and 17.34 ± 13.42 mmHg in hydralazine group. (p=0.136, Not significant). Labetalol and Hydralazine both drugs are first line drugs in severe hypertension in pregnancy as in our study both drugs control blood pressure in similar way.

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