Limitations: ASCT is discouraged in those with Karnofsky score <70, LVEF <40%, Compromised FEV1, DLCO<40% of predicted normal, Creatinine >3 mg/dl, heavily pretreated patients, and Chemorefractory patients. Table 2 shows checklist for pretransplant workup before posting any patient for ASCT. Counseling: Family meeting before HSCT is necessary to counsel and educate regarding role of relatives accompanying inside the bone marrow transplant room and those visiting from outside. Counseling should also be done for fertility preservation and sperm banking. Half of the patients undergoing ASCT are those having multiple myeloma. Table 3 shows the prevalent indications of ASCT in clinical practice. Insertion of catheter: A double lumen catheter (DLC) is inserted in jugular or sublclavian vein under local anesthesia. This serves both for purpose of collection and intravenous access for stem cell transplantation. The catheter placement is confirmed by chest x-ray and the insertion site is maintained clean and dry with regular change of dressings along with flushing. Catheter care may require analgesics, and training to inform signs of symptoms of infection like fever, redness, swelling, drainage, increased tenderness. Catheter is removed after the HSCT at the time of discharge.