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Context:Angiogenesis, the process that leads to the formation of new blood vessels, continues to be a topic of major scientific interest. There is an increasing hope that new discoveries will lead to newer therapies that target angiogenesis as a reliable option for disease therapy.Aims:The objective of this study was to assess the role of vascularity, correlation of morphometric aspects of vascularity, investigate its usefulness in the histopathological classification and prognosis in normal buccal mucosa (NBM), leukoplakia and squamous cell carcinoma (SCC) of buccal mucosa.Materials and Methods:The study sample consisted of 15 cases of NBM, 30 cases of leukoplakia, and 30 cases of SCC of buccal mucosa. The 75 archival samples were stained by hemotoxylin and eosin (H and E) and Masson's trichrome (MT). The stained sections were analyzed using image analysis software.Statistical analysis used:Statistical Package for Social Sciences (SPSS) 12.0 statistical software.Results:The combined mean vessel density (MVD) of all the cases in H and E was 0.1112 and for MT it was 0.2150. The difference of MVD between H and E and MT was statistically significant. The mean MVD in SCC (0.3455) for MT was higher than NBM (0.1314) and leukoplakia (0.1263). The mean MVD increased from stage III (0.3563) to IV (0.5312). It also increased from NBM (0.1314) to hyperkeratosis (0.1505) and decreased from grade I (0.3556) to II (0.2795) of oral SCC (OSCC).Conclusions:MVD can be used as an adjunct with other diagnostic modalities. Further studies are needed to standardize baseline levels for different sites and age groups.

Aims and Objectives:This study was conducted to assess the incidence and prevalence of palatal rugae shapes in the male and female populations of Karnataka and Kerala.Materials and Methods:This study consisted of 100 plaster models of each group, which were equally distributed between both the genders, with an age range of 17–23 years. The rugae patterns were recorded by using Thomas and Kotze classification. Correlation between the rugae shape and population as well as the rugae shape and gender were analyzed using chi-square analysis and discriminant function analysis using the Statistical Package for the Social Sciences Version 22 (IBM Corp).Results:Curved, straight, and wavy rugae patterns were the most common in both Kerala and Karnataka sample populations. Chi-square analysis showed significant differences between the populations for the curved pattern; discriminant function analysis showed significant differences between the populations for the curved and straight patterns. Significant gender differences were found in the curved pattern for Karnataka population and in unification patterns for both populations by Chi-square/Fischer exact test.Conclusions:The curved and straight rugae patterns were significantly more frequent in the Kerala population compared to the Karnataka population. Because of the limited sample size of this study, further cross-sectional studies are suggested.

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