Plexiform neurofibromas are benign tumors arising from visceral or subcutaneous peripheral nerves, which are usually associated with neurofibromatosis type 1. Giant neurofibromas are a surgical challenge because of their vascularity and extensive infiltration and require preoperative and postoperative management strategies. This case report describes a 30 year old female with a giant plexiform neurofibroma of the left gluteal and thigh region (27kg) in association with neurofibromatosis which was resected successfully.