Research in the eld of periodontology has observed a huge upheaval in the last two decades unveiling newer alterations in techniques, methodologies, and material science. The recent centre of attention in periodontal research is an evidence-based approach which offers a bridge from science to clinical practice. Research inculcates scientic and inductive thinking and it promotes the development of logical habits of thinking and organization. In terms of research methodology, the article aim to inform the reader on topics relating to randomized controlled trials in periodontal research, evidence-based dentistry, calibration of clinical examiners and statistics relevant to periodontal research.