This work aims to evaluate the potential effect of Stachys sieboldii MIQ (SS) against oxidative stress induced by hydrogen peroxide (H2O2) in SK‐N‐SH cells and memory enhancement in ICR mice using the passive avoidance test. The effect of SS in cell proliferation was measured by BrdU incorporation assay with dosages of SS from 0 to 2 mg/mL. SS partially antagonized the effect of 150 μM H2O2 on cell proliferation. In vivo study, SS (100, 250, and 500 mg/kg) was administered orally to mice for 4 weeks. SS led to a significantly longer step‐through latency time compared to control mice. Memory enhancing effect of SS (500 mg/kg) was also observed in amnesia model, SS escalate the fear memory (p < .05), increase acetylcholine and choline acetyl transferase level in hippocampus and cortex than nontreated group. These results suggest that SS can be used to manage memory related disorders in animals. Practical applications Acetylcholine is a cholinergic neurotransmitter known for its various medicinal properties, reducing dementia, depression, cancer, inflammation, and is also required to build muscles in the human body. Hence, the development of a choline‐rich source is of great interest. SS is a good source for vitamins especially vitamin B complex, which is a major precursor for choline synthesis in human. Therefore, this study investigates the memory enhancement effects of Stachys sieboldii MIQ (SS), a choline‐rich plant, in SK‐N‐SH cells and an in vivo animal model. SK‐N‐SH cells and mice treated with SS exhibited memory ameliorative effects. This study sheds light on using plant‐based products as potential functional foods and nutraceuticals for cognition improvement. The results of this study could serve as a foundation for further research on SS extract as a source of choline and promotes the consumption of Stachys sieboldii on a large scale.

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Onion peel (OP) extract is known as a rich source of flavonoids, mainly quercetin. We hypothesized that OP has hypocholesterolemic effects. To investigate the effect of OP, C57BL/6J mice were divided into 4 dietary groups (=10); normal diet (ND); high cholesterol diet (HC); and high cholesterol diet with 100 or 200 mg OP extract (OP-100 or OP-200, respectively) per kg of body weight. After 12 weeks, lower values of liver weight, serum total cholesterol levels, LDL cholesterol, atherogenic index, cardiac risk factor, hepatic triacylglycerol, and total cholesterol, and higher fecal cholesterol levels were observed in the OP-200 than in the HC group. The hepatic mRNA expression levels of low-density lipoprotein receptors (LDL-R) and cholesterol 7-alpha-monooxygenase (CYP7A1) were high in the OP-200 compared to the HC group. These observations suggest that OP promoted lowering of serum and hepatic cholesterol in mice primarily via fecal excretion.

Siddha system of medicines is known for its herbal in origin. Herbal plays a major role in treating acute and chronic diseases. Cardiovascular diseases (CVDs) is the life-threatening disease that contributes a leading cause of death day by day across the world.A change in lifestyle modification is the one of the risks of CVDs. This review paper attempts to facilitate the cardioprotective activity by providing different types of medicinal plants and its botanical distribution, description, chemical constituents and pharmacological activity. Few important herbs will protect the human being from CVDs and gives health and quality of life. In this paper, the authors explores the effect of cardioprotective activity in medicinal plants as follows, Terminalia chebula (Kadukkai), Piper longum (Thippili), Zingiber officinale (Inji), Tinospora cordifolia (Seenthil), Asparagus racemosus (Thanneervitan), Embelia ribes (Vaaivilangam), Andrographis paniculata (Nilavembu), Nelumbo nucifera (Thaamarai), Allium sativum (Vellaipoondu), Bauhinia variegata (Mantharai).

This work aims to evaluate the potential effects of γ‐amino butyric acid (GABA)‐fortified barley bran against chronic stress induced Sprague‐Dawley rats. Animals were divided into four groups (n = 6), based on diet; control group (C), stress with no treatment (STR + NT), stress plus dietary Panax ginseng at 100 mg/kg (positive control group, STR + PG), and stress plus 0.5% GABA‐fortified barley bran (STR + BB‐G). After 21 days, stress biomarkers and liver toxicity biomarkers were measured. The stress biomarkers adrenocorticotropic hormone (ACTH) and corticosterone were decreased (p < .05) in the STR + BB‐G group compared to the STR + NT group. Similar results were obtained for the liver toxicity biomarkers aspartate transaminase and alanine transaminase (p < .05). The high density lipoprotein cholesterol (p < .05) were higher in the STR + BB‐G group than in the STR + NT group. These results suggest that GABA‐fortified barley bran can potentially be used to manage stress and related disorders in rodents. Practical applications GABA is a neurotransmitter known for its various medicinal properties, which reduces anxiety, depression, insomnia and they also have antihypertensive and anticancer activity. Therefore, the development of GABA‐fortified food is of great interest. This study investigates the anti‐stress effects of GABA‐fortified barley bran in Sprague‐Dawley rats. Animals supplemented with GABA‐fortified barley bran exhibited fewer stress effects. This study sheds light on the potential of functional foods and nutraceuticals with enriched cereals for stress management. The results of this study could serve as a foundation for further research on fortified cereals and promote the consumption of fortified cereals on a large scale.