Amisulpride was gifted by Dr. Reddy's (Hyderabad, India). Labrasol, Transcutol P, lauroglycol 90, capmul MCM were received as gift samples from Gattefosse Company (Mumbai, India). Polyethylene glycol 400 (PEG 400), Polysorbate 80, Oleic acid, coconut oil, Tween 20, Propylene glycol, potassium chloride, Oleic acid, Arachis oil, sodium hydroxide, potassium dihydrogen orthophosphate, potassium chloride were purchased from SD fine chem Ltd (Mumbai, India) are of analytical grade. Methanol and Acetonitrile were purchased from Merck Limited (Mumbai, India). All other chemicals were analytical grade and purchased commercially. Double distilled water was used throughout the study.