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The present study was carried out to elucidate the potential of petroleum ether and methanolic extract of Clerodendron inerme (L.) Gaertn leaves on genomic stability and tissue protection using F1 hybrid mice (C57BL male and Swiss albino female). The dried powdered leaves of C. inerme were extracted successively with petroleum ether and methanol in soxhlet apparatus. The methanolic extract yielded 15.7% w/w and petroleum ether extract yielded 3.0% w/w, respectively. Results revealed that when the C. inerme methanolic extract (CIME) was given alone and with radiation therapy (4 Gy), it was noticed that the intestinal tissues were protected better by methanolic extract 500 mg/kg BW orally in mice as compared to other test groups and radiation control groups. Methanolic extract showed good results in intestinal tissue protection but the percentage chromosomal aberration was not well appreciated in comparison to petroleum ether extract which showed good activity in percentage chromosomal aberration and the total removal of aberrated chromosome.

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