Functionalized bicyclic pyrimidinones and their derivatives are significant heterocyclic scaffolds being their all-around prevalence in biologically potent compounds. In several attempts to explore the different synthetic methodologies for the construction of bicyclic condensed pyrimidinones, different researchers from all across the globe have reported numerous substantial methods. In the present review, considerable work has been critically compiled on the synthesis of substituted and functionalized bicyclic pyrimidinones from 2000 onwards.

A nickel(0)-catalyzed intermolecular [3+2] cycloaddition of bis(alkylidenecyclopropanes) with diazenes such as diethyl or diisopropyl azodicarboxylate gave pyrazolidine-1,2-dicarboxylates in moderate to good yields (61–72%).

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