Congenital heart disease (CHD) is present in approximately 50% of patients with trisomy 21 (T21) and Turner syndrome (TS). According to the American Academy of Pediatrics, every patient with these genetic disorders should have a postnatal echocardiogram. T21 is usually associated with atrioventricular (30%-60%), atrial (16%-21%), or ventricular septal defects (14%-27%). TS is usually associated with left-sided heart disease. However, the spectrum of CHD in these genetic disorders is wider than those mentioned lesions. More cardiac surgical procedures are offered to these patients and that has influenced positively their life expectancy for some CHD conditions. Single ventricular anatomy is associated with high mortality in these genetic disorders (49% in T21 and 83%-91% in TS). The goal of this article is to describe the spectrum of CHD, screening guidelines, and cardiac surgical outcomes in patients with T21 or TS with CHD.

This is the first prospective study to confirm the safety and tolerability of REG in patients with ESRD.

This trial supports the routine administration of IV-aminophylline to reduce the frequency and severity of adverse effects associated with regadenoson-stress.

The aim of this study was to understand how endurance time, a proxy for physical fitness, has changed in healthy inner-city children and adolescents in the past three decades. This was a retrospective cross-sectional study. This study used exercise stress test in a laboratory of an inner-city teaching hospital. We reviewed all consecutive healthy children and adolescents who underwent an exercise Bruce protocol treadmill test from 1983 to 2010. The study population was divided into five groups of 5-year intervals based on the year of testing. Temporal trend in endurance time was analyzed, adjusting for gender, ethnicity, age, and body mass index (BMI). We analyzed the records of 435 healthy children and adolescents (mean age 12.6 ± 3.2 years, 57% males).There was a significant difference in the mean endurance time between children grouped in 5-year intervals (P < 0.001) with a significant downward trend in endurance time over the years (P < 0.001), especially after 2001. In contrast, there was no statistically significant change in the mean BMI between children grouped in 5-year intervals (P = 0.205). Multivariate linear regression model demonstrated that the date of testing was independently predictive of endurance time, adjusting for age, gender, BMI, and ethnicity (P < 0.001). Gender was the strongest independent predictor of endurance time, followed by age, BMI, and ethnicity. There is a downward trend in endurance time over the 27-year period among inner-city children and adolescents. Temporal decline in endurance time was independent of factors known to affect this parameter, such as age, gender, BMI, and ethnicity. Factors such as deconditioning due to sedentary lifestyle and lack of motivation to endure on the treadmill among later generations may have played a role in such decline.