The PMH graduate faculty believes that they have developed strategies to meet this challenge and to help build a PMH workforce that will maintain the centrality of the relationship in PMH practice.

No abstract

As essential components of gene expression networks, transcription factors regulate neural circuit assembly.GS homeobox 1(gsx1) is expressed in the developing visual system; however, no studies have examined its role in visual system differentiation. In zebrafish, retinal ganglion cell (RGC) axons terminate in ten arborization fields (AFs) in the optic tectum (TeO) and pretectum (Pr). Pretectal AFs (AF1-AF9) mediate distinct and essential visual behaviors, yet we understand very little about their development compared to AF10 in the TeO. Usinggsx1zebrafish mutants, immunohistochemistry, and transgenic lines, we observed thatgsx1is required for vesicular glutamate transporter,slc17a6b, expression in the Pr, but not overall neuron number.gsx1mutants have normal eye morphology, yet exhibit impaired vision, and a significantly reduced volume of RGC axons innervating the Pr and TeO, including loss of AF7. Consistent with this, prey capture is reduced ingsx1mutants. Timed laser ablation ofslc17a6b-positive neurons reveals that they aide directly in AF7 formation. This work is the first to implicategsx1in establishing cell identity and functional neural circuits in the visual system.

“Silent No More” is the story of a resilient 58-year-old man who has a complex history of alcohol use disorder, depression, HIV, and social isolation. The important factors that contribute to depression, stigma, and social isolation are reviewed. Using these factors, a comprehensive approach to the patient’s problems and needs is presented. The evidence for treatment of depression and depression cofactors for people living with HIV is reviewed. Education about mental health, substance use disorders, and trauma must be presented. Syndemics also must be discussed. Comprehensive mental health care involves medication and nonmedication strategies. Because people living with HIV are living longer, their quality of life must be addressed in relation to the information presented.