No abstract

2005 Multi-membered N-heterocycles R 0690 A Versatile Approach for the Synthesis of 1-Methyl-4H[1,2,4]triazolo[4,3-a][1,4]benzodiazepine N 5 -Oxide. -Title triazolobenzodiazepines (VIII) and the corresponding methyl-substituted N-oxide (XI) are synthesized starting from chloroacetyl isatin (I), using hydrazine to build the triazole ring. -(GUPTA, A.; SIROHI, R.; SHASTRI, S.; KISHORE*, D.; J. Indian Chem.

A Green Chemistry Approach to the Synthesis of Isatoic Anhydrides from Anthranilic Acid Derivatives. -The title compounds (III) (7 examples) are prepared in an efficient one-pot synthesis under solvent-free conditions using microwave heating. The method is compared to the conventional one. -(CHAKRAVORTY, R.; SIROHI, R.; KISHORE*, D.; J. Indian Chem. Soc. 83 (2006) 5, 519-521; Dep. Chem., Banasthali Vidyapith Women's Univ., Banasthali 304 022, Rajasthan, India; Eng.) -H. Toeppel 08-172

ABSTRACT. A novel synthetic approach developed by the use of a microwave (MW) assisted one pot protocol to the synthesis of methyl-1,4-benzodiazepin-2-one-5-carboxylate (2) derivatives for which N-chloroacetylisatin was employed with an elegant success to afford the formation of 5-methyl carboxylate derivatives of 1,4-benzodiazepines from its reaction with methanolic hexamine. We have utilized MW technique in the present work in conducting the reaction of carboxylate ester derivative (2) with several selected primary and secondary amines 3, 4, 5, 6, 7, and 8 which had the previous history of being biologically active in the literature, to generate the corresponding carboxamide derivatives (9-14).

Objective:To determine the salivary fluoride levels after toothbrushing with dentifrices containing 458 ppm and 1000 ppm of fluoride and to compare salivary fluoride levels of two dentifrices at different intervals of time.Materials and Methods:In total, 50 children in the age group of 6-12 years were selected. The individuals were randomly divided into two groups using either 458 ppm or 1000 ppm fluoride dentifrice, respectively. Whole saliva samples were collected prior to brushing, immediately after brushing, and at subsequent intervals after brushing into sterile test tubes.Results:Data collected were evaluated using unpaired t-test. Salivary fluoride level following the use of 458 ppm fluoride dentifrice was significantly lower than the level found following the use of 1000 ppm dentifrice, but the levels were above the baseline values even after 1 h.Conclusion:There was considerable salivary fluoride retention after brushing with fluoride dentifrices.