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Meta-analyses were conducted to investigate the relationship of sperm DNA fragmentation on pregnancy outcome using in-vivo fertilization, IUI, routine IVF and ICSI. Couples with no known infertility problems were 7.0 times (CI 3.17, 17.7) more likely to achieve a pregnancy/delivery if the DNA fragmentation index (DFI) was <30% (n = 362, P = 0.0001) using in-vivo fertilization. Infertile couples using IUI were 7.3 times (CI 2.88, 18.3) more likely to achieve a pregnancy/delivery if their DFI was <30% (n = 518, P = 0.0001). With routine IVF, infertile couples were approximately 2.0 times (CI 1.02, 2.84) more likely to become pregnant if their DFI was <30% (n = 381, P = 0.03). For ICSI and/or routine IVF, the results showed a non-significant trend where infertile couples were 1.6 times (CI 0.92, 2.94) more likely to achieve a pregnancy/delivery if the DFI was <30% (n = 323,P = 0.06). The in-vivo and IUI meta-analyses were similar, indicating that IUI infertility patients with <30% DFI have as good a statistical probability of obtaining a pregnancy/delivery as in-vivo presumably fertile couples with the same DFI. These meta-analyses show that the Sperm Chromatin Structure Assay infertility test was significantly predictive for reduced pregnancy success using in-vivo, IUI and routine IVF, and to a lesser extent ICSI fertilization.

This study reports the isoflavone contents of 210 soybean cultivars grown in South Dakota and explores possible relations between isoflavone contents and agronomic characteristics. Total isoflavone contents (normalized) ranged from 1161 to 2743 μg/g. A number of agronomic characteristics were documented for each variety including maturity group, hilum color, disease resistance, seed weight, yield, maturity (in days), and plant height. Varieties in maturity group I had significantly higher total isoflavones when compared to maturity group 0. Hilum color was related to differences in genistin, daidzein, and genistein content. No differences in isoflavone content were observed based on disease resistance profiles. Genistein content was found to be negatively correlated with yield, days of maturity, and plant height. Weak but significant correlations also existed between these agronomic characteristics and other isoflavones.

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