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Detergent-disrupted virions of Rous sarcoma virus can synthesize in vitro an infectious viral DNA. Infectivity of this DNA was determined in transfection assays at the end-point dilution. It was found that the specific infectivity of the crude endogenous reaction product was 34 infectious units/µg. The endogenous reaction yielded up to 8.5 × 10-7 infectious units per biologically active input virion, i. e., nearly 0.1–1 infectious molecules. The possible structure of these molecules is discussed.

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