Spleen tyrosine kinase (Syk) is a key regulator of cell signaling induced by cytokines or Fc receptor engagement. However, the role of Syk in rheumatoid arthritis (RA) is not known yet. We investigated the pathways activated by Syk in tumor necrosis factor-␣ (TNF␣)-stimulated fibroblast-like synoviocytes (FLS) using the novel Syk inhibitor N4- (2,2-dimethyl-3-oxo-4H-pyrid
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