In summary, our study describes an influence of SAT topography on adiponectin serum levels and provides first evidence that incipient atherosclerosis is associated with low serum levels of this adipocytokine.
We show here that increased oxidative stress is associated with migraine and contributes to migraine-related metabolic risk like nitrosative stress, an atherogenic lipid profile and hyperinsulinemia. Our data suggest that oxidative stress may represent a key event in the pathophysiology of migraine and a suitable therapeutic target.
We show here that normal weight migraineurs exhibit independent of aura symptoms an atherogenic lipid profile, which shares common features with obesity-related lipid alterations. Our data suggest that migraine is associated with a higher risk for cardiovascular disease and its clinical consequences.
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