Relevance. Acute urinary retention (AUR) adversely affects the the patient’s quality of life and the prognosis of myocardial infarction (MI). Aim. To evaluate features of the coronary arteries state in men under 60 years old with myocardial infarction complicated by AUR to improve prevention and outcomes. Material and methods. The study included men aged 19-60 years old with MI were studied. The patients were divided into two age comparable groups: I - study group, with AUR - seven patients; II - control, without it - 132 patients. A comparative analysis of the coronary angiography indicators, AUR risk analysis (Pearson's Chi-square) were performed. Results. The study group did not differ from the control group in the numbers of affected arteries and the extent of the lesion, its localization and depth. The study group was characterized by complete occlusion of the coronary arteries (in the study group: 100%; control: 32.7%; p = 0.003), the absence of revascularization (0 and 17.0%; respectively; p = 0.03), re-current lesions (22.7 and 3.7%; p ˂ 0.0001), as well as a large maximum stenosis (100.0 ± 0 and 92.8 ± 10.6%; p = 0.03). The same parameters were associated with the risk of AUR development. Conclusions. Men under than 60 years old with AUR in MI are characterized by a higher incidence of complete occlusions of the coronary arteries and failure to perform revascularization. These angiographic parameters indicate that the patient belongs to the high-risk group for severe MI and the development of AUR. It is advisable to use them for the timely imple-mentation of preventive measures and for predictive modeling.

Relevance. Acute urinary retention (AUR) and associated arrhythmias negatively affect the prognosis of myocardial infarction (MI). Aim. To evaluate the features of heart rhythm and conduction disturbances and electrocardio-graphic changes in men under 60 years old (y.o.) with AUR in MI to improve understanding of the mechanisms of development and prevention. Material and methods. The study included men aged 19-60 years old with MI and AUR were studied. The patients were divided into two age comparable groups: I - study group, with AUR - 22 patients; II - control, without it - 644 patients. A comparative analysis of the fre-quency of observation of arrhythmias and ECG changes in the selected groups, analysis of the influence of various factors (Pearson's Chi-square) on the risk of arrhythmia in the study group were performed. Results. The study group was dominated by: ECG signs of enlargement of the left (I: 90.9 and II: 65.0%; p=0.03) and right ventricle (9.1 and 2.0%, respectively; p=0.03 ), sinus brady- (50.0 and 13.1%; р˂0.0001) and tachycardia (36.4 and 15.8%; р=0.01), asystole (36.4 and 1.9% ; p˂0.0001), atrial fibrillation and flutter (AF and AFl) (31.8 and 7.2%; p˂0.0001), complete atrioventricular (AV) blocks (27.3 and 2.5%; p˂0.0001), ventricular fibrillation (18.2 and 4.2%; p˂0.0001) and ventricular tachycardia (18.2 and 3.9%; p=0.001). For the de-velopment of arrhythmias in the study group, the most important were: smoking (absolute risk (AR): 85.7%; p=0.03); non-anginal variants of the disease course (AR: 89.5%; relative (RR) - 2.68; p=0.02); lower IM localization (100.0%; 1.57; p=0.03); overweight without obesity (100.0%; 2.0; p=0.01), duration ≥10 years (100.0%; 1.67; p=0.02); non-ulcerative digestive diseases (94.1%; 2.35; p=0.006). For the development of life-threatening arrhythmias (ven-tricular fibrillation and asystole) in the study group, arterial hypertension (AH) with a crisis course (66.7%; 6.3; p=0.02), penetrating lesions (33.3%; p=0.04) and body weight ≥110 kg or more (100.0%; p=0.0001). Conclusions. The men under 60 y.o. with AUR, MI are characterized by both life-threatening arrhythmias (ventricular fibrillation and tachycardia, complete AV block and asystole) and less dangerous its (AF and AFl). For the development of arrhythmias in MI and AUR, the fol-lowing causes were: smoking; nonanginal variants of MI; lower localization of the lesion; overweight without obesity for ≥10 years; non-ulcer digestive diseases. For the occurrence of life-threatening arrhythmias in MI and AUR, an additional role was played by: AH, obesity and penetrating lesions.

Abstract. Relevance. Acute urinary retention (AUR) in myocardial infarction (MI) negatively affects the course and prognosis of the disease. Aim. To evaluate the MI clinical course of AUR development during the acute and subacute periods of disease in men under 60 years old to improve prevention and outcomes. Materials and methods. The study included men aged 19-60 years with type I myocardial in-farction. Patients were divided into two age-comparable groups: I - study group, with ACR - 22 patients; II - control, without urination disorders - 644 patients. A comparative analysis of the features of the medical history and clinical course in the selected groups were performed. Pear-son's Chi-square method was used to analyze the risks of ACR development. Results of the study. The study group differed from the control group in a higher frequency of cardiac arrhythmias and conduction disorders at the onset of coronary artery disease (I: 61.9; II: 24.9%; p = 0.0007), higher incidence of multiple MI complications (100 and 44.0%; ; respectively; p < 0.0001), severe and extremely severe condition of patients (59.0 and 19.6%; p < 0.0001). Asystole (absolute risk: 42.1%; relative: 18.0; p < 0.0001), hydrothorax (41.7%; 15.9; p < 0.0001), the patient’s severe condition in the first hours of illness (30%; 36.5; p < 0.0001), and onset of CHD with heart rhythm and conduction disturbances (7.7%; 4.6; p = 0.0001) were the most significant ACR predictors. Conclusion. Patients with ACR are characterized by a more severe MI course. Combinations of listed above factors indicate an increased risk of development this complication. It is advisable to use them for predictive modeling and the formation of risk groups for timely prevention.

For the first time, medicinal plants of arid landscapes of the south of Russia were studied for amino acid composition, vitamins. The features of the accumulation of organic acids and vitamins in medicinal plants were established, the concentrations were correlated from the type and genus of the plant. The component composition of amino acids of the studied LR samples was studied. A total of 9 amino acids were found, of which 5 are irreplaceable. The content of aminoacidum in the studied samples have high levels of variation within the species list, regardless of the plant family, and have a range of total amino acid composition ranging from 3.28% to 12.42%. In general, the content of AC prevails in plants of the species Plantágo májor (12.42%), Polygonum aviculare (9.47%), Capsella bursa-pastoris (8.06%). The lowest indicators of the total number of AC were found for plants of the species Artemisia austriaca (3.28%), Cardaria draba (3.71%). The content of oxalic acid is noted in the aster family and astragalus of the esparcet family of legumes < 250 mg/kg, in other plant samples the content of oxalic acid is > 200 mg/kg. This may be due to the fact that many plants of arid territories accumulate nutrients in the form of salts of organic acids. Studies have shown that the vitamin C content in almost all plant samples is higher than the vitamin K content, with the exception of the common shepherd's purse and the bird's bittern, this may be due to specific features and growing conditions. The percentage of sugar in plant samples has a high level of variation from 1.05 to 5.32%, this may also be due to the specific species of plants, regardless of the family affiliation. A direct correlation has been established between the contents of biologically active organic acids and nutrients in vegetation. The study showed that organic acids have a strong variation in indicators and depend on the type of selected plants and the properties of the functional zone of growth.

Relevance. Acute kidney injury (AKI) and arrhythmias negatively affect the prognosis of myocardial infarction (MI). Aim. To evaluate the features of heart rhythm and conduction disturbances and electrocardiographic changes in men under 60 years old (y.o.) with AKI in MI to improve understanding of the mechanisms of development and prevention. Material and methods. The study included men aged 19-60 years old with MI and AKI were studied. The patients were divided into two age comparable groups: I - study group, with AKI - 25 patients; II - control, without it - 486 patients. A comparative analysis of the frequency of observation of arrhythmias and ECG changes in the selected groups, analysis of the influence of various factors (Pearson's Chi-square) on the risk of arrhythmia in the study group were performed. Results. The compared groups did not differ in the frequency and structure of cardiac arrhythmias and conduction disorders. For the development of arrhythmias in the study group, the most important were: diastolic (absolute risk (AR): 100%; relative (RR) - 5.3; p = 0.02) 120 mm Hg. and more and systolic (AR: 83.3%; RR: 5.3; p = 0.02) blood pressure (BP) 180 mm Hg or more, the early and late left ventricular (LV) filling velocity relationship less than 0,7 (AR: 66.7%; p = 0.002), left atrial 38 mm or more (AR: 53.3%; p = 0.007), LV end-systolic volume index (52.4 ml / m2 or more) and LV end-diastolic index (88.0 ml / m2 and more) (AR: 66.7% each; RR: 4.67 each; p = 0.01). For the development of life-threatening arrhythmias (ventricular fibrillation and asystole) in the study group, a body weight of 110.0 kg or more was of additional importance (AR: 50.0%; p = 0.01). New arrhythmias in the subacute MI period were recorded only in the control group of patients. Conclusions. For AKI in MI in men under 60 y.o., there were no specific heart rhythm and conduction disturbances. For the arrhythmias development in MI with AKI, signs of pronounced hypertension, dilatation of the left heart and LV systolic and diastolic dysfunction are primary importance. Obesity is an additional importance for the life-threatening arrhythmias development in MI with AKI.