Metronidazole has been widely used in clinical dentistry, is specifically anti-anaerobic in nature and known for its effective antibacterial activity against anaerobic cocci as well as Gram-negative and Gram-positive bacilli. It has been used both systemically and topically in the treatment of periodontal disease. Application of its uses in paediatric dentistry is limited. The importance of metronidazole in paediatric dentistry has not been clearly demonstrated. Hence, the purpose of this short communication was to review uses of metronidazole in children with dental problems.