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A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR,1H NMR, and Mass spectral data. All the final compounds were evaluated for theirin vitroantimicrobial activity.

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Agents. -9 Thiazole derivatives of type (IV) are prepared and tested for their analgesic and antiinflammatory activities. Derivatives (IV) appear to possess significant peripheral anti-nociceptive activity. (IVb) shows antiinflammatory activity comparable with that of the standard. -(KALKHAMBKAR, R. G.; KULKARNI*, G. M.; SHIVKUMAR, H.; RAO, R. N.; Eur.