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The cone crusher is an indispensable equipment in complex ore mineral processing and a variant of the cone crusher is the inertia cone crusher. A real-time dynamic model based on the multibody dynamic and discrete element method is established to analyze the performance of the inertia cone crusher. This model considers an accurate description of the mechanical motions, the nonlinear contact, and the ore material loading response. Especially the calibration of ore material simulated parameters is based on the Taguchi method for the Design of Experiments. For model verification, the industrial-scale experiment was conducted on a GYP1200 inertia cone crusher. Two different drive speeds were included in the experiments, and the testing devices were used to acquire crusher performances, for instance, displacement amplitude, power draw, product size distribution, and throughput capacity in order to accurately compare simulation results. The preliminary model can be qualitatively evaluated the flow pattern of particles and quantitatively evaluated the crushing force distribution in the concave. Furthermore, the simulation predicts the variety of crusher performances using the drive speed and the fixed cone mass as input variables. The simulation model provides novel insight regarding the improvement of linings wear period, lowering manufacturing cost, and obtaining optimal operation parameters.