The study investigated the antimicrobial activity of the essential oil extract of Ocimum gratissimum L. (EOOG) against multiresistant microorganisms in planktonic and biofilm form. Hydrodistillation was used to obtain the EOOG, and the analysis of chemical composition was done by gas chromatography coupled with mass spectrometry (GC/MS) and flame ionization detection (GC/FID). EOOG biological activity was verified against isolates of Staphylococcus aureus and Escherichia coli, using four strains for each species. The antibacterial action of EOOG was determined by disk diffusion, microdilution (MIC/MBC), growth curve under sub-MIC exposure, and the combinatorial activity with ciprofloxacin (CIP) and oxacillin (OXA) were determined by checkerboard assay. The EOOG antibiofilm action was performed against the established biofilm and analyzed by crystal violet, colony-forming unit count, and SEM analyses. EOOG yielded 1.66% w/w, with eugenol as the major component (74.83%). The MIC was 1000 µg/mL for the most tested strains. The growth curve showed a lag phase delay for both species, mainly S. aureus, and reduced the growth level of E. coli by half. The combination of EOOG with OXA and CIP led to an additive action for S. aureus. A significant reduction in biofilm biomass and cell viability was verified for S. aureus and E. coli. In conclusion, EOOG has relevant potential as a natural alternative to treat infections caused by multiresistant strains.

In this review, we explore some aspects of Pseudomonas aeruginosa virulence factors that are related to disease development in healthy organisms and resistance to antibiotics. This pathogen is one of the most clinically and epidemiologically important bacteria in Brazil, being the major cause of opportunistic infections. Among the virulence factors, biofilm formation acting of manner different in the organism. Furthermore, we review several P. aeruginosa genes that act in antimicrobial resistance, such as β-lactamases against β-lactamers. The resistance to pied-lactamases in P. aeruginosa is associated to resistance to the broad-spectrum cephalosporin. On the other hand, there is a group of synthetic broad-spectrum antibiotics acting on DNA synthesis is the quinolones that destroy HIGHLIGHTS  The bacterium has become the most antibiotic-resistant hospital disease  P. aeuroginosa developed a mechanism antimicrobial against classes of β-lactamases Rocha, A.J.; et al.

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Objetivo: Analisar as produções científicas sobre a avaliação da autoestima de pacientes oncológicos, submetidos ao tratamento quimioterápico. Metodologia: Trata-se de uma revisão integrativa da literatura, onde foi formulada a seguinte questão PICo (não-clínica): Quais as evidências  cientificas apontam as mudanças na autoestima dos pacientes oncológicos submetidos ao tratamento quimioterápico? Resultados: As alterações na autoestima em pacientes oncológicos estão relacionadas a efeitos adversos da quimioterapia, como a alopecia, e ao estado psicológico baixo associado à depressão, comprometimento familiar, isolamento social, estresse, e alguns sintomas como náuseas, vômitos, anorexia, debilidade física, que provocam sentimento de impotência e desesperança afetando diretamente na autoestima. A produção dos bundles de intervenção propôs estimular a pratica de atividade física e outras atividades de lazer em pacientes oncológicos, oferecer um programa de apoio psicossocial integrado para os pacientes e seus acompanhantes no enfrentamento da doença e mudança na autoestima, Orientar sobre o surgimento da alopecia durante a quimioterapia, e os efeitos negativos na autoimagem, Promover atividades de apoio ao retorno ao trabalho e aconselhamento ocupacional em pacientes oncológicos, Desenvolver atividades de embelezamento e do uso de adornos em pacientes submetidos a quimioterapia. Considerações Finais: O tratamento quimioterapico pode ser considerado um fator determinante nas alterações da autoestima, pois possibilita a ocorrência de inúmeros impactos na vida do paciente oncológico, tais coomo, fisíco, emocionais e sociais.

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