Clear cell acanthoma or Degos' acanthoma is a distinct disease concerning its
clinical, histopathological, and immunohistochemical features. Its pathologic nature
- whether neoplastic or reactive - is still under dispute among researchers. The
disease shows a chronic course and often presents with a single papulonodular lesion
on the lower limbs of adults. However, cases with multiple lesions, sometimes
occurring in an eruptive fashion, and with clear variation in the size and shape of
the cutaneous lesions have been reported. So far, five cases in which the lesions
were exclusively located in the nipple area have been reported, all in Korean women.
Four of these cases mimicked eczema and one, a polypoid nodule. The aim of this
article is to present clinical, histopathological, and immunohistochemical features
of two additional cases in Brazilian women with similar nipple topography.
Behçet's disease is a chronic inflammatory disease of unknown aetiology, characterized by recurrent oral and genital aphthous ulcerations, uveitis, skin lesions and other multisystem affections associated with vasculitis. Different types of vessels, predominantly veins, can be affected in Behçet's disease. The frequency of vascular lesions in Behçet's disease, such as superficial and deep venous thromboses, arterial aneurysms and occlusions, ranges between 7-29%. Budd-Chiari syndrome is a rare and serious complication of Behçet's disease and implies thrombosis of the hepatic veins and/or the intrahepatic or suprahepatic inferior vena cava. We report a case of a 25-year-old man with Behçet's disease that developed Budd-Chiari syndrome. The correlation of dermatological, pathological and imaging studies confirmed the diagnosis.
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