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The addition of hollow glass spheres is interesting to reduce the thermal conductivity of the concrete pieces. This work aims to evaluate the concrete with addition of hollow glass microsphere with different combinations of dosage in concrete concerning strength and workability. Slump tests were performed in each dosage of concrete in order to evaluate the effect of glass microspheres in concrete mix. In each age of curing concrete, bodies-specimens underwent ultrasound to estimate the homogeneity of concrete with hollow glass microspheres, and testing of compressive strength. The analysis of the results shows that for some formulations, the addition of hollow glass microspheres imparts high mechanical strength to compressive strength above 30MPa at all analyzed cure periods. The workability of the concrete had to be substantially reduced, showing no workability improvement due to the addition of hollow glass microsphere.

Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol–gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles.

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