ABSTRACT Cancer is one of the main causes of morbidity (conditions that change quality of life and health) and mortality (death). The highest prevalence of cancer in children is blood cancer (Leukemia). One of the factors that affect a person's quality of life is overprotective, related to the behavior undertaken by a person. The aim of this study was to determine the correlation overprotective behavior of parents to the quality of life of children with Acute Lympoblastic Leukimia. The study was conducted on 30  respondents in Poly Oncology Seruni RSUD Arifin Achmad Riau Province taken with purposive sampling technique. This stdy is quantitative with correlation design using cross sectional approach. The results showed that most parents have overprotective behavior as many as 18 people (60,0%), most children have poor quality of life as many as 18 people (60,0%). Based on chi square statistic test found that p value 0,024 (<0,05) that means there is correlation between overprotective behavior of parent to quality of life of child with Acute Lympoblastic Leukimia. The suggestion for further research to develop more about the correlation of support systems to the quality of life of children.   Keywords         : Overprotective behavior of parents, quality of life of children, acute lymphoblastic leukimia