Percutaneous administration of "Orthobiologics" offers the advantage of accelerated and functional recovery of musculoskeletal disorders. Stem cell optimizes the biological healing of diseases. The regenerative capacity of mesenchymal stem cells provides a pavement for clinicians to build up an organ of interest in vitro. Mesenchymal stem cells remain the perfect cell based tissue regeneration modality for treatment of musculoskeletal disorders in a minimally invasive environment without any significant morbidity. This article outlines the applications of mesenchymal stem cell administration in various musculoskeletal disorders.

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Recent advances in molecular and nanobiology have led to the identification of specific cytokines that mediate cellular activities which becomes a powerful tool in management of orthopaedic disorders.Platelet rich plasma is a potential "Orthobiologic" agent for treating inflammatory and degenerative musculoskeletal disorders. Platelet rich plasma therapy aimed in rejuvenating the degenerating tissues by neoangiogensis and neoinnervation thus by increasing the texture and biology of the diseased tissues. This article outlines the guidelines for the usage, precautions, pre and post injection events of autologous platelet rich plasma therapy in musculoskeletal disorders.