Abstract-This study was conducted to know the effect of turmeric as immunomodulator in layer chicken against Avian influenza vaccine. This research used DOC that were given turmeric ethanol extract 50% concentration at day 8 until day 21, and Avian influenza vaccine was given at day 15. The bloods sample were collected at day 7, 14, and 21 at brachial vein. It was an experimental research and data were analyzed using t test paired sample. The result of total heterophils before AI vaccine was given showed an increased significant effect (p<0.05) (12.6563 ± 4.60) %, and after vaccine was (19.0000 ± 9.22) %. The results of total basophils before AI was given showed there was no significant effect (p>0.05) (2.9688 ± 1.96) %, and after vaccined was (3.2813 ± 1.76) %. It can be concluded that turmeric has an immunomodulatory effect.

Gene p53 is a tumor suppressor gene that in normal conditions is in ' standby ' mode , several studies show that pivotal point that lead to stimulation of p53 is DNA damage , heat shock , hypoxia, exposure of nitric oxide ( NO ) , the expression of oncogenes and some p53 pathways activation. p53 mechanism as a guardian of genome stability are cell cycle arrest, repair of DNA damaged, induce apoptosis, prevents angiogenesis , invasion and metastasis ability of the tumor. On many tumor , p53 is not loss , but mutated , the p53 mutant was expressed 70 % in lung cancer , and in different frequencies in other cancers . Then the role of p53 as a transcription factor that works to regulate genes involved in tumor suppression is indispensable .

This study aims to see the effectiveness of red betel leaf extract ointment against incision wounds in white rats. The tannin and saponin compounds found in red betel leaf extract function to stimulate the formation of collagen which plays a role in the wound healing process. This study used an experimental research method with the test materials being 21 male white rats (Rattus norvegicus), red betel leaf extract on wound adhesions, the total number of erythrocytes and hemoglobin in white rats due to incision wounds, divided into 3 treatment groups with 7 samples. The results of the mean value of wound attachment in the groups P0 18 ± 0.5, P1 8.5 ± 0.4 and P2 6.5 ± 0.0. The mean results of erythrocyte values in the P0 group were 6.16 ± 0.90a, P1 6.46 ± 0.45a, and P2 6.20 ± 0.63a. and the results of the mean hemoglobin values in the P0 group 11.8 ± 1.1a , P1 12.3 ± 0.7a , and P2 12.1 ± 1.2a . The results of the study showed that the administration of red betel leaf extract ointment (Piper crocatum) on wound attachment had a significant effect at a concentration of 45%, because it was believed that red betel leaf extract ointment could increase peristaltic movements. While the total number of erythrocytes and hemoglobin due to incision wounds in white rats (Rattus norvegicus) there was no significant difference.

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