Introduction: The use of electronic prescribing has identified as a strategically important policy to improve health care. Therefore, the purpose of this study was to review the issues related to security, privacy and privacy of electronic copying systems.Material and Methods: A comprehensive review of studies were conducted that published in English, free access to the full text of the article and without time limitation, by searching for keywords in keywords, title and abstract of studies in valid scientific databases Web of Science, Scopus, PubMed and Embase in June 4, 2021. Two researchers reviewed the title and content of searched studies independently. 137 related studies found and finally 25 main articles selected.Results: In general, the results of the study showed that in some countries, there are still no minimum requirements and standards for these systems; But the use of security and privacy protocols has been used in various ways. However, according to other studies, most patients and physicians are concerned about the privacy and security of medical data in the context of these systems. In general, security in an electronic healthcare system includes the seven main components of user authentication, patient confidentiality, licensing issues, scalability, integrity, non-denial, and confidentiality of information sent, processed, and stored.Conclusion: In this study, different protocols were classified into 7 main components. Although there are different protocols to ensure security, privacy and confidentiality issues; But the lack of international security requirements poses a major challenge to the adoption of electronic transcription systems. Given that the majority of patients and physicians were concerned about the issues of privacy and security of medical data, it is necessary for policy makers and managers in this area to pay attention to these issues before implementing these systems and provide a safe environment for implementing these systems. Provide patient privacy.