This study aimed to analyze the differences in serum lactate levels and the incidence of Acute Kidney Injury (AKI) in GDFT-based and standard liquid therapy in major laparotomy surgery with general anesthesia at Dr Soetomo Hospital. The type of research and research design used is a randomized clinical trials. The research design is an experimental study design. The observed study variables were then followed during surgery up to 48 hours after surgery for data retrieval and measurement. Patients covered by the study were patients who underwent elective major laparotomy at GBPT of Dr Soetomo Hospital. The results revealed that the administration of crystalloid solutions in the standard group was more than that of the GDFT group, while the administration of colloidal solutions in the standard group was less than that of the GDFT group. Intraoperative fluid balance in the standard group were larger compared to the GDFT group. The standard group had higher levels of postoperative serum lactate than the GDFT group (p < 0.001). The incidence of AKI in the standard group was 4 (18.2%) and no AKI incidence was found in the GDFT group.