BACKGROUND.Although mania is characteristic of bipolar disorder, it can also occur following focal brain damage. Such cases may provide unique insight into brain regions responsible for mania symptoms and identify therapeutic targets. METHODS.Lesion locations associated with mania were identified using a systematic literature search (n = 41) and mapped onto a common brain atlas. The network of brain regions functionally connected to each lesion location was computed using normative human connectome data (resting-state functional MRI, n = 1000) and contrasted with those obtained from lesion locations not associated with mania (n = 79). Reproducibility was assessed using independent cohorts of mania lesions derived from clinical chart review (n = 15) and of control lesions (n = 490). Results were compared with brain stimulation sites previously reported to induce or relieve mania symptoms. RESULTS.Lesion locations associated with mania were heterogeneous and no single brain region was lesioned in all, or even most, cases. However, these lesion locations showed a unique pattern of functional connectivity to the right orbitofrontal cortex, right inferior temporal gyrus, and right frontal pole. This connectivity profile was reproducible across independent lesion cohorts and aligned with the effects of therapeutic brain stimulation on mania symptoms. CONCLUSION.Brain lesions associated with mania are characterized by a specific pattern of brain connectivity that lends insight into localization of mania symptoms and potential therapeutic targets.

O experimento foi conduzido com o objetivo de comparar dietas peletizada e extrusada para machos revertidos de tilápias do Nilo, de 188,9 a 362,4g. Foram utilizadas cem tilápias do Nilo, distribuídas em um delineamento inteiramente casualidade com dois tratamentos e cinco repetições. A cada cinco dias, registrou-se os dados de temperatura e transparência da água dos tanques. Com relação à conversão alimentar e taxa de sobrevivência, não houve diferença (P>0,05) entre as dietas peletizada e extrusada. O maior ganho de peso diário e taxa de eficiência proteica (P<0,05) foram obtidos com a dieta extrusada, assim como o melhor resultado de uniformidade. Com relação ao custo médio em ração por quilograma ganho em cada tratamento, o menor custo (P<0,05) foi obtido com a dieta peletizada. Concluiu-se que a dieta extrusada proporciona o melhor desempenho, mas o menor custo em ração por quilograma de ganho é obtido com a dieta peletizada.

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Analysis of drift of ichthyoplankton in two channels in the River

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