Polyhydroxybutyrate and chitosan have been studied as materials for drug delivery systems (DDSs) due to their biodegradability and biocompatibility. The aim of this work was to produce amphiphilic polyhydroxybutyrate/chitosan matrices that form porous structures (scaffolds) after swelling in water and arnica extract. The matrices were analyzed by TGA, SEM, XDR, DSC, and FTIR. Thin plate spline interpolation method (TPSIM) was used to predict the swelling of the matrices generating three‐dimensional data fitted, showing the influence of time and concentration variables on both fluids absorption. Polyhydroxybutyrate/chitosan samples containing 60 wt % (weight percent) of chitosan formed a porous structure as they were submitted to arnica loading, and the obtained device was able to deliver arnica in physiological medium. Thus, the produced matrices have a strong potential to perform both as scaffolds and DDS © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47838.

A comparative study between the most used methodologies for the preparation of piperidinyl pyridines (Buchwald-Hartwig reaction, Ullmann reaction and nucleophilic aromatic substitution (S N Ar)) by microwave-assisted piperidination of halopyridines is reported. Our results suggest that the Ullmann reaction is most effective for less reactive halopyridines, while uncatalysed S N Ar is sufficient for more reactive ones.

Sonogashira coupling of iodo-and bromoarenes and acetylenes using PdEnCat ™ 30 in a phosphine-, copper-, amine-, and microwave-free system was developed, which allows for the preparation of a modulator of glutamate receptor mGluR5.

Abstract:The Medicinal Chemistry laboratory of the "Polo de Xistoquímica" of the IQ-UFRJ has been developing projects in the area of Medicinal Chemistry for seven years, conducting research on new anti-hypertensive, antidepressant, antibiotic and antiviral agents. In the last five years, a doctor and six masters in science developed their works in this laboratory, and at this moment, four undergraduate and a master student are working there. Fourteen scientific articles were published in the last five years and two patents are in the process of filing.Keywords: medicinal chemistry, anti-hypertensive, antidepressant, transport P ResumoO laboratório de Química Medicinal do Polo de Xistoquímica do IQ-UFRJ vem desenvolvendo projetos na área de Química Medicinal há sete anos, realizando pesquisas acerca de novos agentes anti-hipertensivos, antidepressivos, antimicrobianos e antivirais. Nos últimos cinco anos, formamos um doutor e seis mestres em ciências, e contamos, no momento, com quatro doutorandos e um mestrando. Foram publicados 14 artigos científicos nos últimos cinco anos e duas patentes estão em processo de depósito. palavras-chave: química medicinal, anti-hipertensivos, antidepressivos, transporte P Joaquim Fernando Mendes da Silva cursou graduação em Farmácia na UFRJ e obteve seu doutoramento em Química Orgânica no Instituto de Química da UFRJ. Realizou estágio pós-doutoral no University College London (UCL) sob a supervisão do Prof. C. Robin Ganellin, FRS. Atualmente orienta teses na área de Química Medicinal, sendo credenciado no Programa de Pós-Graduação em Química. Além da atuação na pós-graduação strictu sensu, é também coordenador do curso