Data from a published double-blind randomized trial comparing olanzapine versus haloperidol in acute mania were used to address the response and tolerability of Latin American patients. Primary efficacy end point was the remission rate (Young Mania Rating Scale score

Our results support the idea that lungs from donors aged 60-70 years can be used safely for lung transplantation with comparable results to lungs from younger donors in terms of postoperative mortality and mid-term survival.

Sir: The use of antipsychotic drugs is frequently associated with sexual dysfunction. Symptoms may concern penile erection, lubrication, orgasm, libido, sexual arousal, or overall sexual satisfaction. Different strategies to treat antipsychoticinduced sexual dysfunction have been developed, including drug holidays, dose reduction, switching to another drug, and use of a number of agents for symptomatic therapy. Within the framework of systematic review for the Cochrane Collaboration, 1 our objective was to review the effectiveness of these strategies for the treatment of antipsychotic-induced sexual dysfunction.Data Sources and Study Selection. The trial register of the Cochrane Schizophrenia Group, the Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, and the PsycLIT databases were searched for relevant trials reported through August 2005 using sexual dysfunction symptoms and antipsychotic terms as keywords (see reference 2 for specific terms). First only randomized controlled trials were searched, and then the search was expanded to all available evidence regardless of level of evidence. The first author of each study was contacted for additional references and for any unpublished trials or data, and the reference lists of all identified studies were inspected for additional studies. Companies involved in production of the principal antipsychotics who offer a drug information service and those involved in the production of the possible agents for symptomatic therapy were also contacted to request additional studies. Study selection, data extraction, and assessment of methodological quality (using a classification recommended by the Cochrane Library 2 ) were performed independently by 2 reviewers (M.M.B. and M.H.).Data Synthesis. Two randomized controlled trials concerning symptomatic drug therapy of antipsychotic-induced sexual dysfunction were identified. 3,4 In one of them 3 (N = 10, crossover), no evidence was found for the effectiveness of selegiline (15 mg) in improving sexual functioning in schizophrenic patients maintained on neuroleptic treatment. Another crossover trial 4 evaluating the administration of sildenafil (flexible doses of 25-50 mg; N = 32) found positive effects in all examined outcomes: number of erections sufficient for penetration, mean duration of erections, frequency of satisfactory intercourse, and satisfaction with treatment.Two open-label trials (N = 10, 5 N = 12 6 ) and 2 case reports 7,8 (each with N = 1) also support the effectiveness of sildenafil at doses of 25 to 100 mg in patients with schizophrenia and schizoaffective disorder. One observational study 9 (N = 8) describes the effectiveness of 25 to 50 mg of imipramine as addon therapy in patients with schizophrenia. Two other open-label studies (N = 10, 10 N = 12 11 ) provide evidence for 100 to 300 mg of amantadine as additional medication in patients with schizophrenia. Observational (N = 8 to 20) and case report (N = 1 to 5) evidence was found for the effectiveness of switching to another antipsychotic ...

et al. Reconstrucción traqueal bajo oxigenación con membrana para circulación extracorpórea para el manejo de una lesión traumática: reporte de caso y revisión bibliográfica. Rev Colomb Cir. 2018;33:211-9. https://doi.org/10. 30944/20117582.64 Reconstrucción traqueal bajo oxigenación con membrana para circulación extracorpórea para el manejo de una lesión traumática: reporte de caso y revisión bibliográfica ResumenIntroducción. El traumatismo traqueal es una condición poco frecuente que puede ser ocasionada por traumas abiertos, cerrados o iatrogénicos; su presentación clínica es variable y el diagnóstico suele ser clínico, apoyándose en la radiografía de tórax, la tomografía cérvico-torácica y la fibrobroncoscopia. Su manejo representa todo un reto médico y quirúrgico, y se requieren múltiples herramientas para su adecuado tratamiento. La terapia con oxigenación con membrana para circulación extracorpórea ha sido ampliamente utilizada en el manejo de pacientes con falla respiratoria aguda, en los cuales los métodos convencionales de asistencia respiratoria mecánica no son suficientes para garantizar una adecuada oxigenación. Caso clínico. Se presenta el caso de una paciente con una lesión traqueal iatrogénica reparada quirúrgicamente, bajo asistencia con oxigenación con membrana para circulación extracorpórea, para garantizar la oxigenación tisular y la adecuada recuperación y supervivencia de la paciente. Conclusiones. La terapia con oxigenación con membrana para circulación extracorpórea es una excelente alternativa para el manejo quirúrgico de las lesiones traqueales complejas que amenazan la vida del paciente, ya que permite brindar un soporte vital y un adecuado intercambio gaseoso durante el procedimiento. Palabras clave: tráquea; traumatismos del cuello; enfermedad iatrogénica; reconstrucción; respiración artificial; oxigenación por membrana extracorpórea. AbstractIntroduction: Tracheal trauma is a rare condition that can be caused by open, closed, or iatrogenic trauma; its clinical presentation is variable and the diagnosis is usually clinical, supported by chest X-ray, thoracic CT and bronchoscopy. Its management represents a medical and surgical challenge, requiring multiple tools for the

Purpose Identifying actionable oncogenic mutations have changed the therapeutic landscape in different types of tumors. This study investigated the utility of comprehensive genomic profiling (CGP), a hybrid capture-based next-generation sequencing (NGS) assay, in clinical practice in a developing country. Methods In this retrospective cohort study, CGP was performed on clinical samples from patients with different solid tumors recruited between December 2016 and November 2020, using hybrid capture-based genomic profiling, at the individual treating physicians’ request in the clinical care for therapy decisions. Kaplan–Meier survival curves were estimated to characterize the time-to-event variables. Results Patients median age was 61 years (range: 14–87 years), and 64.7% were female. The most common histological diagnosis was lung primary tumors, with 90 patients corresponding to 52.9% of the samples (95% CI 45.4-60.4%). Actionable mutations with FDA-approved medications for specific alterations correspondent to tumoral histology were identified in 58 cases (46.4%), whereas other alterations were detected in 47 different samples (37.6%). The median overall survival was 15.5 months (95% CI 11.7 months-NR). Patients who were subjected to genomic evaluation at diagnosis reached a median overall survival of 18.3 months (95% CI 14.9 months-NR) compared to 14.1 months (95% CI 11.1 months-NR) in patients who obtained genomic evaluation after tumor progression and during standard treatment ( P = .7). Conclusion CGP of different types of tumors identifies clinically relevant genomic alterations that have benefited from targeted therapy and improve cancer care in a developing country to guide personalized treatment to beneficial outcomes of cancer patients.